Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex
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چکیده
منابع مشابه
Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination.
We have shown previously that electrolytic lesions of the dorsal hippocampus (DH) produce a severe deficit in contextual fear if made 1 d, but not 28 d, after fear conditioning (). As such, the hippocampus seems to play a time-limited role in the consolidation of contextual fear conditioning. Here, we examine retrograde amnesia of contextual fear produced by DH lesions in a within-subjects desi...
متن کاملHippocampal inactivation disrupts contextual retrieval of fear memory after extinction.
Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of extinction. In experiment 1, rats were conditioned to fear a tone conditional stimulus (CS) and subsequently extinguished either in the same context as con...
متن کاملDorsal hippocampal contributions to unimodal contextual conditioning.
Although there is general consensus that the hippocampus is not critically involved in the acquisition of fear conditioned to an explicit conditioned stimulus (CS), the extent to which the hippocampus participates in contextual fear conditioning remains unclear. To further characterize the potential role of the hippocampus in contextual fear conditioning, the present experiments examined the ef...
متن کاملEFFECTS OF TEMPORARY INACTIVATION OF DORSAL HIPPOCAMPUS ON EXPLICITLY NONSPATIAL, UNIMODAL, CONTEXTUAL FEAR LEARNING By
ii ABSTRACT OF THE THESIS Effects of temporary inactivation of dorsal hippocampus on explicitly nonspatial, Several studies have reported that dorsal hippocampal damage attenuates the of recently acquired contextual fear conditioning. "Context" is often operationalized as the conditioning chamber in which CS-US pairings occurred. However, the hippocampus is known to participate in spatial learn...
متن کاملDifferential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning.
The hippocampus is an essential neural structure in developing contextual memory in a situation in which rapid development of associative learning should occur. We tested a subregion-specific contribution in the hippocampus to memory acquisition and retrieval, using the contextual fear-conditioning paradigm. The current results suggest that all three subregions (i.e., CA3, CA1, and dentate gyru...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2018
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1006207